Ketamine RESOURCES
Dold M, Bartova L, Kasper S: Treatment response of add-on esketamine nasal spray in resistant major depression in relation to add-on second-generation antipsychotic treatment. Int J Neuropsychopharmacol 2020; 23:440–445
Wilkinson ST, Toprak M, Turner MS, et al: A survey of the clinical, off-label use of ketamine as a treatment for psychiatric disorders. Am J Psychiatry 2017; 174:695–696
Office of the Commissioner: FDA approves new nasal spray medication for treatment-resistant depression; available only at a certified doctor’s office or clinic. US Food and Drug Administration, 2019
https://www.fda.gov/news- events/press-announcements/fda-approves-new-nasal-spray-medication-treatment-resistant-depression-available- only-certified
McIntyre RS, Carvalho IP, Lui LMW, et al: The effect of intravenous, intranasal, and oral ketamine/esketamine in mood disorders: a meta-analysis. J Affect Disord 2020; 276:576–584
Papakostas GI, Salloum NC, Hock RS, et al: Efficacy of esketamine augmentation in major depressive disorder: a meta-analysis. J Clin Psychiatry 2020; 81:19r12889
Andrade C: Ketamine for depression, 5: potential pharmacokinetic and pharmacodynamic drug interactions. J Clin Psychiatry 2017; 78:e858–e861
Sanacora G, Frye MA, McDonald W, et al: A consensus statement on the use of ketamine in the treatment of mood disorders. JAMA Psychiatry 2017; 74:399–405
Popova V, Daly EJ, Trivedi M, Cooper K, Lane R, Lim P, Mazzucco C, Hough D, Thase ME, Shelton RC, Molero P, Vieta E, Bajbouj M, Manji H, Drevets WC, Singh JB. Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study. Am J Psychiatry. 2019 Jun 1;176(6):428-438
Bahji A, Vazquez GH, Zarate CA: Comparative efficacy of racemic ketamine and esketamine for depression: a systematic review and meta-analysis. J Affect Disord 2021; 278:542–555 double-blind active-controlled study. Am J Psychiatry 2019; 176:428–438